Chemotherapy has remained the mainstay for the treatment of multiple types of cancers. In particular, topical use of chemotherapy has been used for skin cancers. Though effective, topical chemotherapy has been limited due to adverse effects such as local and even systemic toxicit [....] » Read More
The first-pandemic-outbreaks in Wuhan, China, COVID-19 in the year 2019, caused by SARS-CoV-2, has quickly spread worldwide, badly affecting human civilization, our activity, behavior, food habits, etc., developing different-chronic-diseases, and the current 4th-pandemic-wave als [....] » Read More
Huge antibiotic use caused poison in the gut and contamination of sea and river water. Such contamination caused the generation of a few hundred MDR genes (bla, aac, aph, aad) that inactivate antibiotics. Such bacteria are now located in milk, meat, urine, and feces of animals, f [....] » Read More
Despite the availability of sufficient data on the effects of individual metal exposure on living organisms, a critical knowledge gap still exists in predicting effects of multi-metals particularly on the pituitary-testicular axis. Thus, the aim of the present study was to check [....] » Read More
Snakes and its body parts have been used in folk and traditional medicine of various cultures since ancient time. Evidences in Chinese and Levantine medicinal system suggested the usage of snake shed skin in treatment of several diseases. In Indian traditional medicinal system, a [....] » Read More
Our studies of some Tunisian medicinal and toxic species, carried out in cooperation with Spanish and Italian research groups, have shown several interesting compounds and activities. The in vitro antiproliferative activity of the extracts of Nicotiana glauca and Artemisia campes [....] » Read More
Presently Packaging plays a significant role for New Drug discoveries. The process of selecting materials and the type of packaging also offers an opportunity for the Packaging scientist to look for new biological delivery choices. Most injectable protein products were supplied i [....] » Read More
It has been hypothesized that elevated plasma Homocysteine (Hcy) plays a role in the pathogenesis of Alzheimer’s disease (AD) and age-related cognitive decline. The mechanism of Hcy neurotoxicity in the brain is controversial as well Hcy is a ligand of NMDA receptor. [....] » Read More
Phosphine poisoning is an uncommon but hazardous public health issue. It is widely used as chemical insecticide and pesticide domestically and exposure to this chemical, mostly accidental among children, may lead to fatal symptoms if not managed immediately. Previous studies have [....] » Read More
Title : Countering Bacterial Antibiotic Resistance
A C Matin, Stanford University School of Medicine, United States
Uropathogenic Escherichia coli (UPEC) causes urinary tract infections eg., cystitis, which are treated by gentamicin. The protein ss, encoded by the rpoS gene, controls E. coli general resistance. We discovered that rpoS deletion renders UPEC more sensitive to Gm and other bacter [....] » Read More
Title : Mechanisms of male reproductive toxicity induced by dimethoate insecticide in rats and ameliorating effect of l-carnitine
Mostafa Abbas Shalaby, Cairo University, Egypt
Mechanisms of Dimethoate (DIM) induced – male reproductive toxicity in rats and the ameliorating effect of L-carnitine (LC) were studied. Five groups of male Sprague Dawley rats were distributed into five groups. Group 1: given corn oil (vehicle); Groups 2 and 3 were [....] » Read More
Title : Chemical Carcinogens
Ana Faustino , University of Evora, Portugal
A carcinogen in any agent able to cause cancer in humans or animals, increases cancer incidence or malignancy or shortens the latency period. A chemical is considered carcinogenic after being intensively studied by researchers and after one or more agencies evaluated the evi [....] » Read More
Title : Functionalized Pcl/Pvp Fibrous Mats and Their Potential Application as Wound Dressings
Luis Jesus Villarreal Gomez, Autonomous University of Baja California, Mexico
Wound dressings have been used to clean, cover, and protect the wound from the external environment. However, choosing an adequate dressing will reduce the time of healing, provide cost-effective care, and improve the patient’s quality of life. Electrospun fibers have gaine [....] » Read More
Title : Lead inhibits the odontogenic differentiation potential of dental pulp stem cells by affecting WNT1/?-catenin signaling and related miRNAs expression
Mahshid Hodjat, Tehran University of Medical Sciences, Iran (Islamic Republic of)
Lead (Pb) is a global health problem for humans. Environmental Pb exposure results in blood, saliva, bone, and teeth lead accumulation. Mineralized calcium-rich tissues are the main reservoir of body Pb. Different studies have shown the Pb effect on odontogenesis and teeth h [....] » Read More
Title : Hepato-Renal Protective Potential of Dimethyl Fumarate in Alloxan-Induced Diabetic Mice Model
Ramin Ataee, Mazandaran University of Medical Sciences, Iran (Islamic Republic of)
Diabetes mellitus is a growing epidemic and is the most common cause of chronic kidney disease and liver failure. Despite advances in diabetes-related treatments, the effects of the disease have not yet been adequately reversed or prevented in patients. Therefore, there is an urg [....] » Read More
Title : Occurrence of Cadmium in Boreholes Water in Yenagoa Metropolis of Bayelsa State and the Toxicological Risk Implication
Egbo Walamam Mansi, Bayelsa State Polytechnic, Nigeria
The occurrence of heavy metals in boreholes water at a concentration above recommended level poses serious toxicological risk to public health. This is due to the toxicity of heavy metals such as Mercury, Lead, cadmium and others. Cadmium is very toxic to human health. It is scie [....] » Read More
Title : Occurrence of Cadmium in Boreholes Water in Yenagoa Metropolis of Bayelsa State and the Toxicological Risk Implication
Yaguo Eremasi Benjamin Ikele, Bayelsa State Polytechnic, Nigeria
The occurrence of heavy metals in boreholes water at a concentration above recommended level poses serious toxicological risk to public health. This is due to the toxicity of heavy metals such as Mercury, Lead, cadmium and others. Cadmium is very toxic to human health. It is scie [....] » Read More
Title : Fibromyalgia and Chronic Pain (June 15-16, 2016 Philadelphia, USA) J Pain Relief ISSN: 2167-0846 JPAR an open access journa Fibromyalgia 2016 June 15-16, 2016 Volume 5, Issue 3(Suppl) Page 40 Indoor strains of Aspergillus calidoustus and Aspergillus versicolor emit mycotoxins in guttation droplets
Raimo Mikkola, Aalto University, Finland
Active mold growth indoors is considered a health threat, and there is consensus that inhaling mold can cause health problems for people. However, why active mold growth is a more serious threat than the presence of dried, inactive mycelia (1) and how metabolically active molds r [....] » Read More
Title : Effects of Sodium Hydrosulfide (Nahs) On Cisplatin-Induced Hepatic and Cardiac Toxicity
Esrafil Mansouri, Ahvaz Jundishapur University of Medical Sciences, Iran (Islamic Republic of)
One of the most effective chemotherapeutic drugs for the treatment of the testis, bladder, ovaries, lungs, and neck cancers is Cisplatin (cis-diamminedichloroplatinum (II), CP), which is a platinum-based drug. Although CP is an important anticancer drug in the clinic, it has side [....] » Read More
Title : Study of The Possible Teratogenicity of Daclatasvir on The Pregnant Mice
Nancy Mohamed El Sekily, Alexandria university, Egypt
Congenital birth defects occur in about 5% of all live births. Drugs may account up to 1% of the known causes of birth defects. Hepatitis C virus (HCV) infection is a worldwide health problem. Its prevalence in pregnancy is between 1% and 8% of cases. Daclatasvir (DCV) is one of [....] » Read More