Toxicology 2023 _ Event Postponement

This is to inform that due to some circumstances beyond the organizer control, “2nd Edition of International Conference and Expo on Toxicology and Applied Pharmacology” (Toxicology 2023) Hybrid Event scheduled during June 12-13, 2023 | Rome, Italy has been postponed. The updated dates and venue will be displayed shortly.

Your registration can be transferred to the next edition, if you have already confirmed your participation at the event.

For further details, please contact us at [email protected] or call + 1 (702) 988 2320.

Speaker at Toxicology and Applied Pharmacology 2023 - Amit Gupta
Amit Gupta
Invertis University Bareilly, India
Title : Chronic exposure to multi metals on testicular toxicity in rats

Abstract:

Despite the availability of sufficient data on the effects of individual metal exposure on living organisms, a critical knowledge gap still exists in predicting effects of multi-metals particularly on the pituitary-testicular axis. Thus, the aim of the present study was to check the effects of individual or combined (binary and ternary) exposure to aluminum, copper, and zinc on (i) sperm and testosterone levels (ii) oxidative stress and (iii) structural changes in testis of male Wistar rats. Animals were exposed to aluminum, copper, and zinc either individually (20 mg/kg, orally, once, daily), binary (10 mg/kg each, orally, once daily) or in ternary combination (5 mg/kg, each, orally, once daily) for 24 weeks. The exposure to aluminum, copper individually and in combination led to a significant decrease in sperm counts and an increased oxidative stress compared to the control group. Exposure to zinc caused significant decrease in oxidative stress and an increase in different sperm variables. The exposure to zinc with aluminum or copper had no toxic effects on testis while concomitant exposure to aluminum, copper, and zinc produced more pronounced testicular injury. In summary, while co-exposure to zinc with aluminum or copper produced reproductive toxicity the co-exposure to all the three metals may lead to a significant testicular toxicity and these changes were related to increase in oxidative stress in rats.

Audience Take Away Notes:

  • Principles of Toxicity- Acute, chronic, subacute, subchronic toxicity
  • Metal Toxicity- Single, binary, and tertiary mixtures
  • Biochemical Assays and their determination
  • Reproductive Toxicity Studies
  • Histopathological Studies

Biography:

 Amit Gupta is currently working as Assistant Professor in Department of Pharmacy, Invertis University Bareilly. He has completed his M.Pharm from National Institute of Pharmaceutical Education and Research (NIPER), Raebareli and B.Pharm from MJP Rohilkhand University Bareilly. He was the gold medalist of his batch in B Pharm as well as M. Pharm. He has experience of more than 2.5 years in academics and research. He has also worked as Drug safety officer in Pfizer Drug Safety, Delhi. He has published 3 research articles, 7 review articles, 1 book chapter and filed 1 patent. He has guided more than 45 students of B.Pharm in their final year project works. He has been appointed as Editorial Board Member in Toxicology Communication Journal. He is also review Board Member of peer reviewed National and International Journals such as Plant Cell Biotechnology and Molecular Biology, Asian Journal of Medicine and Health, Asian Journal of Applied Chemistry Research, Journal of Pharmaceutical Research International and African Journal of Biotechnology. Along with it, he has worked as Social Media Coordinator, First Aid Incharge, GPAT Course Instructor, Placement Coordinator, DQAC Coordinator, NAAC Criteria-II Incharge in the department.
 

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