Esrafil Mansouri

Title : Effects of sodium hydrosulfide (NaHs) on cisplatin-induced hepatic and cardiac toxicity

Abstract:

One of the most effective chemotherapeutic drugs for the treatment of the testis, bladder, ovaries, lungs, and neck cancers is Cisplatin (cis-diamminedichloroplatinum (II), CP), which is a platinum-based drug. Although CP is an important anticancer drug in the clinic, it has side effects such as ototoxicity, gastrotoxicity, and neurotoxicity that limit its use. Therefore, one of the important issues is to prevent CP side effects in treating cancer patients. H2S is an extraordinary physiological gas signaling molecule that regulates biological processes such as angiogenesis, proliferation, redox balance, inflammation, and cell death. H2S has also been protected versus Ischemia-reperfusion injury (IRI) in the tissue of numerous organs, including the heart, liver, brain, and lungs. The present study aimed to investigate whether the simplest H2S anion donor (NaHS)  might have a protective effect against cisplatin-induced hepatotoxicity and cardiotoxicity.

Audience Take Away Notes:

• Audiences can learn about the antioxidant and anti-inflammatory properties of the NaHS
• Audiences can get new ideas for further research work on the NaHS
• Other researchers can use this antioxidant compound for other tissue damage caused by oxidative stress in different organs in other research centers.
• Audiences can use and conduct more research due to the practicality of this research to reduce the problems caused by the side effects of other anti-cancer drugs.

Biography:

Esrafil Mansouri received a bachelor's degree in nursing in 1998 from Yazd Shahid Sadoughi University of Medical Sciences, and in 2002 he graduated from Ahvaz Jundihapur University of Medical Sciences in the field of medical histology, and worked on stereology and prostate in his master's degree. In 2010, he graduated from the same university with a PhD in medical histology and did his thesis on diabetic nephropathy. In 2011, he became a member of the academic staff of Jundishapur University of Medical Sciences and is currently a  associate professor of histology in this university. He is working in the field of stem cells and regenerative medicine in this university.