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Speaker at International Conference and Expo on Toxicology and Applied Pharmacology Conference  2022 - Al Borhan Bayazid
Konkuk University , Korea, Republic of
Title : Neuroprotective Role of Sodium Butyrate through Suppressing Inflammation and Modulating Antioxidant Enzymes in vitro and High Fat Diet-fed Mice

Abstract:

The discovery of effective therapeutic agents against neurodegenerative diseases (NDDs) remains challenging. Neurotoxicity, inflammations, and oxidative stress are associating factors of NDDs. Sodium butyrate (NaB) is a short-chain fatty acid found in diet and produced in the gut that reportedly protects against cancer, inflammation, obesity, and so on. We have investigated the neuroprotective effects of NaB in SH-SY5Y cells stimulated with TNF-α. We also used four-week-old male C57Bl/6NTac mice were divided into three groups; the control group, the High Fat Diet (HFD) group, and the HFD + NaB group where mice received 11 mg/kg body weight of NaB with HFD. Our results showed that NaB attenuated cell death and inhibited the NO production and decreased the expression of iNOS and COX-2. NaB notably ameliorated apoptotic regulatory proteins p-53, Caspase-3 and caspase-1 level, and reversed phosphorylation of extracellular signal-regulated kinases and p-38 proteins. We found that NaB restored bodyweight and attenuated P-53, Bcl-2-associated X protein (BAX), and caspase cascades in the brains of HFD-fed mice. NaB ameliorated Glucocorticoid receptor and NLRP3 inflammasome expressions in SH-SY5Y cells and brains of HFD-fed mice. On the other hand, NaB treatment upregulated the expression of the growth factor-related factors PPARγ, CREB, and BDNF in the brain tissues of HFD-fed mice. NaB also suppressed the BAX activation and modulated Nrf-2, HO-1 and MnSOD expression in neuroblastoma cells and in the cerebral cortex of HFD-fed mice. In addition, NaB substantially reversed the Amyloid-beta and Tau activation in SH-SY5Y and BV-2 cells. Altogether, our results suggest that sodium butyrate has potential therapeutic effects against NDDs.

Biography:

Mr. Al Borhan Bayazid studied Applied Biochemistry at the Konkuk University, Korea and graduated as MS in 2020. He then joined the research group of Prof. Beong Ou Lim at Bio Food and Pharmaceuticals Lab, Konkuk University. He received his BSC degree in 2017 from Daffodil International University, Bangladesh. He has published 8 research articles in SCI(E) journals

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